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Hudson Therapeutics, Inc.
  • Home
  • About US
  • PIPELINE
  • INFLAMMASOME
  • NANOBODY
  • News

Inflammasome

Inflammasome Inhibitors?

 lnflammasomes are intracellular multiprotein complex in the innate immune system, the body's first line of defense against pathogen-associated molecular patterns (PAMPs) or host-derived cellular stress signals known as damage-associated molecular patterns (DAMPs). Once activated, inflammasomes produce highly pro­inflammatory cytokines such as IL-1β and IL-18 and induce programed cell death called pyroptosis. Dysregulation of inflammasomes is associated with a vast number of autoimmune and inflammatory disorders.  

Shaperon/Hudson's Inflammasome inhibitors

Novel mechanism of Shaperon/Hudson's Inflammasome Inhibitors

Unlike other inflammasome inhibitors which target to inhibit only the activation phase of inflammasome, Shaperon/Hudson's GPCR19-P2X7 modulation yields multiple advantages over conventional approaches.

  • Suppresses both priming and activation phase of inflammasome pathway, resulting in the suppression of multiple cytokines and chemokines including ll-1β, TNF-α, IL-6, IL-18, etc.
  • Acts selectively on inflammatory immune cells
  • Efficacy variation less likely (GPCR19 is non-polymorphic)
  • Targeting GPCR19, top regulator of inflammasome activation, avoids NLRP3-associated redundant pathways such as NLRP1, NLRC4, AIM2 

 © 2023 Hudson Therapeutics, Inc.

The information presented on this website is derived from the official website of our parent company, Shaperon, Inc. This site is designed exclusively to showcase Hudson Therapeutics, Inc. to potential investors and partners. Please note that we are not responsible for any misuse of the content outside its intended purpose.


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